Dr. Gabrielle Lyon Says we should focus less on burning fat and more on building muscle and strength, is it protects us as we age.
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02:45 There is no correlation between animal protein, cancer and mTOR, only flawed epidemiological data.
03:38 mTOR is driven in a low protein diet high in carbs, with spiking blood sugar and insulin.
03:47 mTOR in the muscle is primarily driven by proteins like leucine. mTOR in the liver is carbohydrate/insulin mediated.
05:18 You need at least double the RDA of .8 grams/kilogram of protein. Your protein intake can be concentrated into two meals, if you are fasting.
06:05 Dr. Lyon finds that patients as young as 25 yrs. have low stomach acid. 98% of her patients have low stomach acid. Many were on PPIs.
08:07 30 grams of high-quality protein 3 times per day is a great place to start. To max out muscle protein synthesis, increase from this in 1 to 2 meals.
10:08 Intuitive eating is a mistake.
13:31 Delta Sleep Inducing Peptide is being used to help reset circadian rhythm.
14:44 RAD 140 is an androgen receptor modulator. BPC 157 (Body Protection Compound) aids in tendon repair.
16:41 Amlexanox is a TBK 1 inhibitor that Dr. Lyon uses it off label to down regulate inflammation in fat cells, increase resting metabolic rate and increase weight loss.
17:49 Tesofensine is a triple uptake inhibitor that effects serotonin, norepinephrine and dopamine, which helps patients lose significant weight and improves cognition.
19:38 People who are obese have an increased inflammatory response to exercise.
23:17 Infectobesity is where the cause of obesity is a reaction to a pathogen or parasite.
27:53 Cardiovascular disease, Alzheimer’s and cognitive impairment begin in your 30s.
31:00 We have no charts for lean muscle mass.
33:32 Our cutoffs for body fat percentage, BMI of 30, are too high. 12 to 18 may be beneficial for a woman still menstruating. Men could range from 8 to 12 to a little higher.
35:53 Dynapenia (age-associated loss of muscle strength) starts in your 30s. Muscle is your largest site for glucose uptake and fatty acid oxidation.
36:30 People with sarcopenia tend to do less, shifting hormones (testosterone, estrogen, progesterone, growth hormone). They eat less and not enough protein.
41:00 With resistance training exertion to significant fatigue is key.
47:25 Branch chain amino acids are not necessary if your protein consumption is adequate. If you are vegetarian or vegan, BCAA are recommended.